DENGUE: Determination of anti-virus IgG / IgM by immunochromatographic method.

Dengue is a disease caused by an arbovirus that has four antigenically distinct serotypes: DEN-1, DEN-2, DEN-3, and DEN-4.

Currently in Brazil circulate the four serotypes that intersect in the occurrence of epidemics, which are generally associated with the introduction of new serotypes in previously unreached areas or alteration of the predominant serotype. Dengue virus is transmitted by the bite of the mosquito of the genus Aedes, which is also responsible for the transmission of other viral diseases.

The World Health Organization (WHO) estimates that 4 billion people live in areas at risk of infection from the disease. Annually, approximately 390 million cases are recorded worldwide. In Brazil, transmission has been occurring continuously, in cyclical outbreaks, the largest of which had around 2 million reported cases.

Dengue can have different clinical presentations and an unpredictable prognosis, its incubation period varies from 3 to 15 days. The illness begins suddenly with a high fever, severe pain in the head and eyes, as well as muscle and joint pain. In the most severe cases, when the fever subsides, around the third or fourth day, bleeding occurs due to bleeding from the skin vessels and internal organs that characterize dengue hemorrhagic fever. In these cases, the clinical picture worsens rapidly, showing signs of circulatory insufficiency, intense and continuous abdominal pain, pale skin, bleeding from the nose, mouth and gums and red spots on the skin, which can cause death.

Dengue diagnosis is usually made by serology to determine the presence of antibodies against the virus in the blood or specific antigens, varying their plasma concentrations according to the moment of initiation of the infection.

NS1 is a protein that appears in detectable concentrations during dengue infection, it appears on the first day with a decrease from the fourth day, disappearing around the fifth, sixth day after the onset of symptoms.

IgM appears on average 5 to 8 days after symptoms and can last 30 to 90 days, while IgG appears on average after 14 days and can persist for life.

Given the importance of this disease, RenyLab is committed to quality by providing rapid tests with results in 20 minutes, with high rates of sensitivity and specificity with certified efficacy and strict quality control.

The Renylab Dengue Immunotest is a solid phase immunochromatographic test that qualitatively and differentially detects IgG, IgM antibodies against the four serotypes of dengue virus in human serum and plasma.

The test is fast, safe and represents an important tool for the treatment of patients with suspected dengue.